Completing a grant application can take 40 hours or more. We want to help you navigate the process.
Where to begin
Before you begin, ask yourself the following questions:
- Have I read the Notice of Funding Opportunity (NOFO)? Do I understand it?
- Is my organization eligible to apply, based on the eligibility criteria in the NOFO?
- Does my organization have the technical expertise, personnel, and financial capacity to successfully implement the project described in the NOFO?
- Are all my organization’s stakeholders supportive of applying for this grant?
- Is my organization prepared to successfully implement the project within the budget we're proposing?
Be sure you can answer “yes” to each of these questions. If you can, you’re ready to apply.
How we help you through the process
Our application guides help you prepare and submit your application through grants.gov.
When you apply, you need to fill out an SF-424 application form.
We created a guide for each of these forms:
- New: How to Apply – HRSA Application Guide (PDF - 315 KB)
- This updated version replaces the HRSA Standard and Research & Related (R&R) Application Guides, merging them into one document for NOFOs posted on or after May 1, 2026.
- HRSA Standard Application Guide (PDF - 755 KB)
- Available until 9/30/2026 for NOFOs posted prior to May 1, 2026.
- HRSA Research & Related (R&R) Application Guide (PDF - 5 MB)
- Available until 9/30/2026 for NOFOs posted prior to May 1, 2026.
- HRSA Two-Tier Application Guide (PDF - 883 KB)
- HRSA Research & Related Two-Tier Application Guide (PDF - 801 KB)
Note: If you use assistive technology, you may not be able to access information in these files. For help, please email DGP@hrsa.gov.
Remember: these guides give you general HRSA information about the application and submission process. Refer to the Notice of Funding Opportunity (NOFO) for specific instructions.
How to write a strong application
Applications must adhere to the page limits in the NOFO. Be brief, but precise as you describe:
- Goals and objectives
- Define them clearly
- Be specific
- Need
- The need for the service or activity that the grant will support
- Your organization's track record in fulfilling that need
- Response and impact
- Show how you plan to achieve the program’s purpose
- Include supporting data whenever possible
- Resources and capabilities
- Elaborate on your organization’s knowledge, staffing, and fiscal stability
- Explain how these ensure you can carry out your proposal and meet the goals of the grant program
- Budget
- A realistic plan that matches your goals and objectives
- Include a narrative that justifies the costs
Follow our ten tips
- Allow plenty of time to gather required information.
- Submit well before the deadline.
- Place all information in the order we request.
- Write clearly.
- Complete all application elements and responses to the program requirements.
- Do not assume that reviewers are familiar with your organization, service area, barriers to health care, or health care needs in your community.
- Think about the review criteria when you write the application.
- Provide accurate and honest information.
- Include candid accounts of problems and realistic plans to address them.
- If you omit any required information or data, explain why.
- Match content in tables, charts, and attachments with the proposal narrative.
- Your budget should reflect the proposed activities.
- Fill out forms accurately and completely.
Many applications fail to receive a high score because reviewers:
- Cannot follow the applicant’s thought process.
- Determine that application parts do not fit together.
Your application should show that you'll be responsible with public funds.
- An expired SAM.gov registration is the top reason applications are rejected.
- Reviewers also reject applications because of file issues. Be sure to:
- Stay within the Grants.gov 50-character limit for file names.
- Avoid special characters in the file name. See the list of allowed characters.
- Save in the correct version of Adobe Acrobat.
- Submit files only in an accepted format.
- Do not use attachments for information we require in the body of the application.
- Be sure to reference all tables and attachments to the appropriate text in the application.
- Upload the attachments in the order the NOFO requires.
Before you apply, review your entire application to ensure you have:
- Complied with page limits.
- Included all components in the application checklist.
We will not:
- Consider additional information or materials you submit late.
- Accept emailed applications or supplemental materials once we receive your application.